Multidisciplinary Approach to Epizootiology and Pathogenesis of Bat Rabies Viruses in the United States
Identifieur interne : 000196 ( Main/Exploration ); précédent : 000195; suivant : 000197Multidisciplinary Approach to Epizootiology and Pathogenesis of Bat Rabies Viruses in the United States
Auteurs : J. A. Ellison [États-Unis] ; S. R. Johnson [États-Unis] ; N. Kuzmina [États-Unis] ; A. Gilbert [États-Unis] ; W. C. Carson [États-Unis] ; K. C. Vercauteren [États-Unis] ; C. E. Rupprecht [États-Unis]Source :
- Zoonoses and Public Health [ 1863-1959 ] ; 2013-02.
English descriptors
Abstract
Zoonotic disease surveillance is typically initiated after an animal pathogen has caused disease in humans. Early detection of potentially high‐risk pathogens within animal hosts may facilitate medical interventions to cope with an emerging disease. To effectively spillover to a novel host, a pathogen may undergo genetic changes resulting in varying transmission potential in the new host and potentially to humans. Rabies virus (RABV) is one model pathogen to consider for studying the dynamics of emerging infectious diseases under both laboratory and field conditions. The evolutionary history of RABV is characterized by regularly documented spillover infections and a series of notable host shifts. Within this context, enhanced field surveillance to improve detection of spillover infections will require validated techniques to non‐invasively differentiate infected from non‐infected individuals. In this study, we evaluate the use of infrared thermography to detect thermal changes associated with experimental RABV infection in big brown bats (Eptesicus fuscus) in a captive colony. Our results indicated that 62% of rabid bats had detectable facial temperature decreases (−4.6°C, SD ± 2.5) compared with pre‐inoculation baseline values. These data suggest potential utility for discriminating rabid bats in natural field settings. In addition, focusing upon RABV circulating in the United States between 2008 and 2011, we confirmed spillover events of bat RABV among carnivores and identified cross‐species transmission events caused by four lineages of RABV associated with insectivorous bats. Additionally, our analysis of RABV glycoprotein sequences identified substitutions in antigenic sites that may affect neutralizing activity associated with monoclonal antibodies proposed for use in human post‐exposure prophylaxis. This study provides a glimpse into RABV pathobiology and spillover dynamics among and between bats and a variety of mesocarnivores.
Url:
DOI: 10.1111/zph.12019
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001354
- to stream Istex, to step Curation: 001353
- to stream Istex, to step Checkpoint: 000031
- to stream Main, to step Merge: 000197
- to stream Main, to step Curation: 000196
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multidisciplinary Approach to Epizootiology and Pathogenesis of Bat Rabies Viruses in the United States</title><author><name sortKey="Ellison, J A" sort="Ellison, J A" uniqKey="Ellison J" first="J. A." last="Ellison">J. A. Ellison</name></author><author><name sortKey="Johnson, S R" sort="Johnson, S R" uniqKey="Johnson S" first="S. R." last="Johnson">S. R. Johnson</name></author><author><name sortKey="Kuzmina, N" sort="Kuzmina, N" uniqKey="Kuzmina N" first="N." last="Kuzmina">N. Kuzmina</name></author><author><name sortKey="Gilbert, A" sort="Gilbert, A" uniqKey="Gilbert A" first="A." last="Gilbert">A. Gilbert</name></author><author><name sortKey="Carson, W C" sort="Carson, W C" uniqKey="Carson W" first="W. C." last="Carson">W. C. Carson</name></author><author><name sortKey="Vercauteren, K C" sort="Vercauteren, K C" uniqKey="Vercauteren K" first="K. C." last="Vercauteren">K. C. Vercauteren</name></author><author><name sortKey="Rupprecht, C E" sort="Rupprecht, C E" uniqKey="Rupprecht C" first="C. E." last="Rupprecht">C. E. Rupprecht</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:338E58762D98676FDB1FC9507A10515635E64CC5</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/zph.12019</idno><idno type="url">https://api.istex.fr/document/338E58762D98676FDB1FC9507A10515635E64CC5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001354</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001354</idno><idno type="wicri:Area/Istex/Curation">001353</idno><idno type="wicri:Area/Istex/Checkpoint">000031</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000031</idno><idno type="wicri:doubleKey">1863-1959:2013:Ellison J:multidisciplinary:approach:to</idno><idno type="wicri:Area/Main/Merge">000197</idno><idno type="wicri:Area/Main/Curation">000196</idno><idno type="wicri:Area/Main/Exploration">000196</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Multidisciplinary Approach to Epizootiology and Pathogenesis of Bat Rabies Viruses in the United States</title><author><name sortKey="Ellison, J A" sort="Ellison, J A" uniqKey="Ellison J" first="J. A." last="Ellison">J. A. Ellison</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of High‐Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Johnson, S R" sort="Johnson, S R" uniqKey="Johnson S" first="S. R." last="Johnson">S. R. Johnson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> United States Department of Agriculture, National Wildlife Research Center, Fort Collins, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Kuzmina, N" sort="Kuzmina, N" uniqKey="Kuzmina N" first="N." last="Kuzmina">N. Kuzmina</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of High‐Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Gilbert, A" sort="Gilbert, A" uniqKey="Gilbert A" first="A." last="Gilbert">A. Gilbert</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of High‐Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Carson, W C" sort="Carson, W C" uniqKey="Carson W" first="W. C." last="Carson">W. C. Carson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of High‐Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Vercauteren, K C" sort="Vercauteren, K C" uniqKey="Vercauteren K" first="K. C." last="Vercauteren">K. C. Vercauteren</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> United States Department of Agriculture, National Wildlife Research Center, Fort Collins, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Rupprecht, C E" sort="Rupprecht, C E" uniqKey="Rupprecht C" first="C. E." last="Rupprecht">C. E. Rupprecht</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of High‐Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Zoonoses and Public Health</title><idno type="ISSN">1863-1959</idno><idno type="eISSN">1863-2378</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-02">2013-02</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="46">46</biblScope><biblScope unit="page" to="57">57</biblScope></imprint><idno type="ISSN">1863-1959</idno></series><idno type="istex">338E58762D98676FDB1FC9507A10515635E64CC5</idno><idno type="DOI">10.1111/zph.12019</idno><idno type="ArticleID">ZPH12019</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1863-1959</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bats</term><term>experimental infection</term><term>rabies virus pathogenesis</term><term>surveillance</term><term>thermography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Zoonotic disease surveillance is typically initiated after an animal pathogen has caused disease in humans. Early detection of potentially high‐risk pathogens within animal hosts may facilitate medical interventions to cope with an emerging disease. To effectively spillover to a novel host, a pathogen may undergo genetic changes resulting in varying transmission potential in the new host and potentially to humans. Rabies virus (RABV) is one model pathogen to consider for studying the dynamics of emerging infectious diseases under both laboratory and field conditions. The evolutionary history of RABV is characterized by regularly documented spillover infections and a series of notable host shifts. Within this context, enhanced field surveillance to improve detection of spillover infections will require validated techniques to non‐invasively differentiate infected from non‐infected individuals. In this study, we evaluate the use of infrared thermography to detect thermal changes associated with experimental RABV infection in big brown bats (Eptesicus fuscus) in a captive colony. Our results indicated that 62% of rabid bats had detectable facial temperature decreases (−4.6°C, SD ± 2.5) compared with pre‐inoculation baseline values. These data suggest potential utility for discriminating rabid bats in natural field settings. In addition, focusing upon RABV circulating in the United States between 2008 and 2011, we confirmed spillover events of bat RABV among carnivores and identified cross‐species transmission events caused by four lineages of RABV associated with insectivorous bats. Additionally, our analysis of RABV glycoprotein sequences identified substitutions in antigenic sites that may affect neutralizing activity associated with monoclonal antibodies proposed for use in human post‐exposure prophylaxis. This study provides a glimpse into RABV pathobiology and spillover dynamics among and between bats and a variety of mesocarnivores.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Colorado</li><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Ellison, J A" sort="Ellison, J A" uniqKey="Ellison J" first="J. A." last="Ellison">J. A. Ellison</name></region><name sortKey="Carson, W C" sort="Carson, W C" uniqKey="Carson W" first="W. C." last="Carson">W. C. Carson</name><name sortKey="Gilbert, A" sort="Gilbert, A" uniqKey="Gilbert A" first="A." last="Gilbert">A. Gilbert</name><name sortKey="Johnson, S R" sort="Johnson, S R" uniqKey="Johnson S" first="S. R." last="Johnson">S. R. Johnson</name><name sortKey="Kuzmina, N" sort="Kuzmina, N" uniqKey="Kuzmina N" first="N." last="Kuzmina">N. Kuzmina</name><name sortKey="Rupprecht, C E" sort="Rupprecht, C E" uniqKey="Rupprecht C" first="C. E." last="Rupprecht">C. E. Rupprecht</name><name sortKey="Vercauteren, K C" sort="Vercauteren, K C" uniqKey="Vercauteren K" first="K. C." last="Vercauteren">K. C. Vercauteren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/RenardV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000196 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000196 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= RenardV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:338E58762D98676FDB1FC9507A10515635E64CC5
|texte= Multidisciplinary Approach to Epizootiology and Pathogenesis of Bat Rabies Viruses in the United States
}}
| This area was generated with Dilib version V0.6.27. |  |